Stem cell factor

SCF can exist both as a transmembrane protein and a soluble protein. Stem cell factor is a cytokine that binds to the c-KIT receptor (CD117). This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. It functions as a hematopoietic cytokine that triggers its biologic effect by binding to c-kit (the SCF receptor) (Table 58-7). The biology of stem cell factor and its receptor C-kit.

Author information: (1)Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia.

Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction. SCF on its own cannot drive noncycling hematopoietic progenitor . Stem - cell factor ( SCF ) is also known as kit ligan mast cell growth factor, or steel factor. The average concentration of SCF in normal human serum is 3. Serum SCF concentrations are . SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy.

Together with other cytokines such as . A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood cells and increases the number and actions of these cells in the blood.

Stem Cell Factor Human Recombinant produced in E. Find product specific information including CAS, MSDS, protocols and references. Find MSDS or SDS, a COA, data sheets and more information. M acetic acid with no preservative. This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration.

In adults, it functions pleiotropically, while mostly noted for its continued . While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloi erythroi megakaryocytic, lymphoi germ . Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

Processing Kit ligand signal peptide Soluble KIT ligand Motif Extracellular Helical Cytoplasmic UP Sites UniProtKB SCOP domains 4-helical cytokines Secstruc PDB Validation 1EXZ. Alternative Name: SCF , c-Kit ligan KL, Steel factor, MGF. Non-glycosylated protein, containing 1amino acids. Reducing and Non-reducing . SCF binds to the receptor known as c-Kit (CD117) and is thought to play a critical role in the maintenance or survival of hematopoietic stem cells.

Human SCF shows no activity on murine cells, but murine and rat SCF are active on human cells. SCF stimulates the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture.

Description, SCF is a stromal cell-derived cytokine synthesized by fibroblasts and other cell types. SCF promotes proliferation and early differentiation of cells at the level of multipotential .